| IgA anti-transglutaminase autoantibodies at type 1 diabetes onset are less frequent in adult patients and are associated with a general celiac-specific lower immune response in comparison with nondiabetic celiac patients at diagnosis. | |
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MedLine Citation:
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PMID: 22815294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac-specific humoral immunoreactivity occurs similarly to that in nondiabetic patients at celiac disease (CD) diagnosis. RESEARCH DESIGN AND METHODS: IgA anti-transglutaminase autoantibody (IgA-tTGAb) was detected in 654 new-onset DM1 sera. IgA-tTGAb(+) DM1 sera were subsequently analyzed for IgG-tTG, deamidated gliadin (DGP), and actin antibodies, and results were compared with those found in 83 screen-detected nondiabetic patients at CD diagnosis. RESULTS: A total of 12.8% DM1 sera were IgA-tTGAb(+), with a lower autoantibody frequency in adult patients aged >18 years (6.8 vs. 15.1%, aged ≤18 years; P = 0.005). IgA-tTGAb titers, IgG-tTGAb, and DGPAb frequency/titers and mean number of celiac-autoantibody positivities per patient were significantly lower in IgA-tTGAb(+) DM1 compared with nondiabetic CD patients. CONCLUSIONS: Age of diabetes onset is negatively associated with risk of CD. The celiac-specific humoral immunoreactivity at DM1 onset is significantly lower compared with that found in nondiabetic patients at CD diagnosis. |
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Authors:
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Claudio Tiberti; Francesca Panimolle; Margherita Bonamico; Blegina Shashaj; Tiziana Filardi; Federica Lucantoni; Raffaella Nenna; Francesco Costantino; Andrea Lenzi; Susanna Morano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-18 |
Journal Detail:
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Title: Diabetes care Volume: 35 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-21 Completed Date: 2013-02-20 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 2083-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Rome Sapienza, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Aged Autoantibodies / blood* Celiac Disease / etiology, immunology* Child Child, Preschool Diabetes Mellitus, Type 1 / complications, immunology* Female Humans Immunoglobulin A / immunology* Infant Male Middle Aged Transglutaminases / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulin A; EC 2.3.2.13/Transglutaminases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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