Document Detail


Ifosfamide Chemotherapy and Nonconvulsive Status Epilepticus: Case Report and Review of the Literature.
MedLine Citation:
PMID:  24151171     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We present a patient with peritoneal carcinosarcoma who was treated with the alkylating agent ifosfamide and experienced a rapid decline in mental status. Electroencephalogram (EEG) displayed generalized periodic epileptiform discharges, which raised suspicion for nonconvulsive status epilepticus (NCSE). Following administration of midazolam, the patient's clinical condition and EEG improved. We review the 8 documented cases of ifosfamide-induced NCSE, and demonstrate the similarity in clinical features when compared with ifosfamide neurotoxicity that is not classified as NCSE. EEG findings suggesting an ictal pattern are subtle and heterogeneous, but they are essential for a diagnosis. Since it is unlikely that EEGs are uniformly obtained in instances of ifosfamide neurotoxicity, many cases of NCSE may go unrecognized.
Authors:
Daniel Taupin; Rikki Racela; Daniel Friedman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-22
Journal Detail:
Title:  Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS)     Volume:  -     ISSN:  1550-0594     ISO Abbreviation:  Clin EEG Neurosci     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101213033     Medline TA:  Clin EEG Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
New York University School of Medicine, New York, NY, USA.
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