| If tocolytic magnesium sulfate is associated with excess total pediatric mortality, what is its impact? | |
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MedLine Citation:
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PMID: 9699773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Magnesium and Neurologic Endpoints Trial was a randomized controlled trial (RCT) done to learn whether or not receiving magnesium sulfate during preterm labor could prevent cerebral palsy. Unexpectedly, in the tocolytic arms of the trial, seven (including one set of twins) of 46 cases assigned to receive magnesium ended in total pediatric mortality (fetal + neonatal + postneonatal), compared to none of 47 cases assigned to other tocolytics ending in death. The difference between the two treatment arms is highly statistically significant (risk difference 15.2%; 95% confidence interval 4.8, 25.6; P = .006). If this relationship is confirmed by experimentation with animals or through the conduct of a large RCT at other institutions, it is possible that tocolytic magnesium will be found to be associated with the deaths of several thousand newborns in the United States annually. If the true excess total pediatric mortality is 10%, and if magnesium accounts for 40% of all tocolytics used, then tocolytic magnesium increases the absolute number of infant deaths by about 4800 every year. |
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Authors:
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R Mittendorf; P Pryde; B Khoshnood; K S Lee |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 92 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-03 Completed Date: 1998-09-03 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 308-11 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Illinois, USA. robert@babies.bsd.uchicago.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fetal Death
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chemically induced* Forecasting Humans Infant Infant, Newborn Infant, Newborn, Diseases / chemically induced*, mortality* Magnesium Sulfate / adverse effects* Tocolytic Agents / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Tocolytic Agents; 7487-88-9/Magnesium Sulfate |
| Comments/Corrections | |
Comment In:
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Obstet Gynecol. 1999 Jan;93(1):159-60
[PMID:
9916978
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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