Document Detail

If tocolytic magnesium sulfate is associated with excess total pediatric mortality, what is its impact?
MedLine Citation:
PMID:  9699773     Owner:  NLM     Status:  MEDLINE    
The Magnesium and Neurologic Endpoints Trial was a randomized controlled trial (RCT) done to learn whether or not receiving magnesium sulfate during preterm labor could prevent cerebral palsy. Unexpectedly, in the tocolytic arms of the trial, seven (including one set of twins) of 46 cases assigned to receive magnesium ended in total pediatric mortality (fetal + neonatal + postneonatal), compared to none of 47 cases assigned to other tocolytics ending in death. The difference between the two treatment arms is highly statistically significant (risk difference 15.2%; 95% confidence interval 4.8, 25.6; P = .006). If this relationship is confirmed by experimentation with animals or through the conduct of a large RCT at other institutions, it is possible that tocolytic magnesium will be found to be associated with the deaths of several thousand newborns in the United States annually. If the true excess total pediatric mortality is 10%, and if magnesium accounts for 40% of all tocolytics used, then tocolytic magnesium increases the absolute number of infant deaths by about 4800 every year.
R Mittendorf; P Pryde; B Khoshnood; K S Lee
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  92     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-03     Completed Date:  1998-09-03     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  308-11     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Illinois, USA.
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MeSH Terms
Fetal Death / chemically induced*
Infant, Newborn
Infant, Newborn, Diseases / chemically induced*,  mortality*
Magnesium Sulfate / adverse effects*
Tocolytic Agents / adverse effects*
Reg. No./Substance:
0/Tocolytic Agents; 7487-88-9/Magnesium Sulfate
Comment In:
Obstet Gynecol. 1999 Jan;93(1):159-60   [PMID:  9916978 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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