Document Detail

I(f) in non-pacemaker cells: role and pharmacological implications.
MedLine Citation:
PMID:  16713285     Owner:  NLM     Status:  MEDLINE    
Pacemaker channels play a major role in the generation of sinoatrial rhythmic activity. However, their expression is not confined to specialized myocardial cells, such as primary and subsidiary pacemakers. Electrophysiological and molecular data collected over the last ten years have demonstrated that f-channels are also present in non-pacemaker cardiomyocytes, and become upregulated in cardiac hypertrophy and failure. Mislocalized expression and/or overexpression of f-channels are a consequence of electrophysiological remodeling and, from a clinical point of view, may represent an arrhythmogenic mechanism in heart failure, a condition associated with a high risk for sudden cardiac death. The potential arrhythmogenic role of I(f) and the availability of selective f-channel blockers cause I(f) to be a suitable therapeutic target in heart disease.
Elisabetta Cerbai; Alessandro Mugelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-03-28
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  53     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-23     Completed Date:  2006-07-31     Revised Date:  2011-11-24    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  416-23     Citation Subset:  IM    
Center of Molecular Medicine CIMMBA, Department of Preclinical and Clinical Pharmacology, Viale G. Pieraccini 6, 50139 Firenze, Italy.
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MeSH Terms
Heart Atria / cytology
Heart Diseases / drug therapy*,  physiopathology
Heart Rate*
Heart Ventricles / cytology
Ion Channels / antagonists & inhibitors,  physiology*
Myocytes, Cardiac / physiology
Ventricular Function
Ventricular Remodeling
Grant Support
Reg. No./Substance:
0/Ion Channels

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