| I(f) in non-pacemaker cells: role and pharmacological implications. | |
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MedLine Citation:
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PMID: 16713285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pacemaker channels play a major role in the generation of sinoatrial rhythmic activity. However, their expression is not confined to specialized myocardial cells, such as primary and subsidiary pacemakers. Electrophysiological and molecular data collected over the last ten years have demonstrated that f-channels are also present in non-pacemaker cardiomyocytes, and become upregulated in cardiac hypertrophy and failure. Mislocalized expression and/or overexpression of f-channels are a consequence of electrophysiological remodeling and, from a clinical point of view, may represent an arrhythmogenic mechanism in heart failure, a condition associated with a high risk for sudden cardiac death. The potential arrhythmogenic role of I(f) and the availability of selective f-channel blockers cause I(f) to be a suitable therapeutic target in heart disease. |
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Authors:
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Elisabetta Cerbai; Alessandro Mugelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-03-28 |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 53 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-23 Completed Date: 2006-07-31 Revised Date: 2011-11-24 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
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Languages: eng Pagination: 416-23 Citation Subset: IM |
Affiliation:
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Center of Molecular Medicine CIMMBA, Department of Preclinical and Clinical Pharmacology, Viale G. Pieraccini 6, 50139 Firenze, Italy. elisabetta.cerbai@unifi.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart Atria / cytology Heart Diseases / drug therapy*, physiopathology Heart Rate* Heart Ventricles / cytology Humans Ion Channels / antagonists & inhibitors, physiology* Myocytes, Cardiac / physiology Ventricular Function Ventricular Remodeling |
| Grant Support | |
ID/Acronym/Agency:
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GGP05093//Telethon |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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