Document Detail


Ieodoglucomides A and B from a marine-derived bacterium Bacillus licheniformis.
MedLine Citation:
PMID:  22360451     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 μg/mL, respectively.
Authors:
Fakir Shahidullah Tareq; Ji Hye Kim; Min Ah Lee; Hyi-Seung Lee; Yeon-Ju Lee; Jong Seok Lee; Hee Jae Shin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-24
Journal Detail:
Title:  Organic letters     Volume:  14     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-06-12     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1464-7     Citation Subset:  IM    
Affiliation:
Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
Bacillus / chemistry
Drug Screening Assays, Antitumor
Glycoconjugates / chemistry,  isolation & purification*,  pharmacology
Humans
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Glycoconjugates; 0/ieodoglucomide A; 0/ieodoglucomide B
Comments/Corrections
Erratum In:
Org Lett. 2013 Apr 19;15(8):2071

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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