Document Detail


Idiotype vaccination in multiple myeloma induced a reduction of circulating clonal tumor B cells.
MedLine Citation:
PMID:  12576327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myeloma cells express the idiotype (Id)-specific antigen that may be targeted by Id vaccination. Six patients with stage I IgG myeloma were immunized with the autologous purified M component together with the adjuvant cytokines interleukin 12 (IL-12) alone or in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF). The effect of Id vaccination on circulating clonal tumor B cells was monitored by a real-time allele-specific oligonucleotide polymerase chain reaction method. No other treatment was given. Reduction of blood tumor mass was observed in 4 of 6 patients, with one patient achieving a complete molecular remission in blood. In 3 of these 4 patients an Id-specific T-cell response was induced. In the remaining 2 patients with an unchanged level of blood tumor cells, one patient mounted a T-cell response, whereas the other did not. No significant change in the serum M protein level was noted. Id vaccination may target clonal B cells, suggesting that this strategy might be conducive to achieving tumor control. The clinical significance of these findings remains to be established.
Authors:
Thomas Rasmussen; Lotta Hansson; Anders Osterborg; Hans Erik Johnsen; Håkan Mellstedt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-02-06
Journal Detail:
Title:  Blood     Volume:  101     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-20     Completed Date:  2003-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4607-10     Citation Subset:  AIM; IM    
Affiliation:
Herlev Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
B-Lymphocytes / drug effects,  pathology*
Cancer Vaccines / pharmacology*
Clone Cells / drug effects,  pathology
Cytokines / administration & dosage,  therapeutic use
Humans
Immunization
Immunoglobulin Idiotypes / pharmacology*
Multiple Myeloma / pathology,  therapy*
Myeloma Proteins / administration & dosage,  immunology,  therapeutic use
Neoplastic Cells, Circulating / drug effects*,  pathology
Polymerase Chain Reaction / methods
Remission Induction / methods
T-Lymphocytes / immunology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cancer Vaccines; 0/Cytokines; 0/Immunoglobulin Idiotypes; 0/Myeloma Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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