Document Detail


Idiopathic uric acid lithiasis: epidemiologic and metabolic aspects.
MedLine Citation:
PMID:  7154174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of 264 patients with urolithiasis those with pure uric acid or urate stones were compared to those with other types of calculi for differences in epidemiologic factors and uric acid, calcium and phosphate metabolism. Patients with uric acid stones were predominantly older men. These patients had comparatively lower incomes and spent less money on food but consumed more alcohol. The urinary pH was lower than in the other groups. The absence of abnormally elevated serum uric acid levels and elevated 24-hour urinary uric acid excretion suggests this variety of uric acid lithiasis to be idiopathic in nature. This finding is supported by the results of standardized oral purine loading, which showed no post-loading differences in serum levels and revealed urinary concentrations in 12 patients with pure uric acid stones and 10 normal subjects. However, there is evidence to suggest that this condition may be a precursor of primary gout. Hereditary mechanisms are absent and the relapse rate is the same as in patients with other stones. Therefore, our results suggest the existence of an idiopathic variety of uric acid lithiasis that, at least in central Europe, occurs more frequently than previously assumed. The condition is not inherited, alcohol consumption is a major etiologic factor and there is no evidence of a causative role of abnormalities in purine metabolism.
Authors:
O Zechner; H Pflüger; V Scheiber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  128     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1219-23     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Alcohol Drinking
Calcium Oxalate / metabolism
Calcium Phosphates / metabolism
Female
Gout / metabolism
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Phosphates / metabolism
Purines / metabolism
Socioeconomic Factors
Uric Acid / metabolism*
Urinary Calculi / etiology,  metabolism*
Urine
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 0/Phosphates; 0/Purines; 25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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