| Idiopathic thrombocytopenic purpura: current issues for pathogenesis, diagnosis, and management in children and adults. | |
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MedLine Citation:
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PMID: 12932309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current issues for idiopathic thrombocytopenic purpura (ITP) in children and adults are reviewed. Appropriate initial management of ITP in children is controversial. Some physicians favor specific treatment, whereas other physicians advocate only supportive care until the expected spontaneous remission occurs. In adults, ITP is typically persistent. Treatment is appropriate only for severe and symptomatic thrombocytopenia because prevention of bleeding is the only goal. If patients do not respond to initial glucocorticoid treatment, splenectomy is the appropriate second modality, resulting in sustained remissions in more than 66% of patients. For patients who have severe and symptomatic thrombocytopenia after splenectomy, treatment options are unclear. Intensive immunosuppression may be effective, but stimulation of platelet production by thrombopoietin may also be effective. Because major bleeding in ITP is rare, physicians must be certain that the adverse effects of treatment are not worse than the risks of bleeding caused by ITP. |
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Authors:
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James N George |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hematology reports Volume: 2 ISSN: 1540-3408 ISO Abbreviation: Curr. Hematol. Rep. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-22 Completed Date: 2003-11-12 Revised Date: 2006-07-31 |
Medline Journal Info:
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Nlm Unique ID: 101151358 Medline TA: Curr Hematol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 381-7 Citation Subset: IM |
Affiliation:
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Hematology/Oncology Section, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA. jim-george@OUHSC.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Female Humans Infant, Newborn Pregnancy Pregnancy Complications, Hematologic Purpura, Thrombocytopenic, Idiopathic / complications, diagnosis*, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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