| Idiopathic thrombocytopenia in childhood. Edinburgh experience 1962-82. | |
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MedLine Citation:
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PMID: 3798080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective review of 136 children with idiopathic thrombocytopenia assesses the prognostic significance of various presenting parameters and the effect of therapy. Initial haemoglobin, white cell count, actual platelet count, splenomegaly, hepatomegaly and lymphadenopathy had no significant effect upon the final outcome. Cases of acute I.T.P. were associated with a higher incidence of preceding infection, a shorter history of bleeding and a preponderance of males. The presence of greater than 20 per cent lymphocytes in the bone marrow was associated with a longer time to achieve a normal platelet count (p = 0.05). Steroid therapy shortened the time for acute cases of I.T.P. to obtain a normal platelet count (p = 0.05), but had no effect on long-term prognosis. Chronicity occurred in 25 children (18%) and nine of these had spontaneous remissions. Immunosuppressive therapy was ineffective, but nine out of 12 children were cured by splenectomy. Mortality was 0.7 per cent (one death) and general morbidity was low. |
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Authors:
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C Hoyle; P Darbyshire; O B Eden |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scottish medical journal Volume: 31 ISSN: 0036-9330 ISO Abbreviation: Scott Med J Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1987-02-19 Completed Date: 1987-02-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2983335R Medline TA: Scott Med J Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 174-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Child Child, Preschool Chronic Disease Female Follow-Up Studies Hemorrhage / etiology Humans Infant Infection / complications Leukocyte Count Male Platelet Count Prognosis Purpura, Thrombocytopenic / blood, complications*, therapy Recurrence Registries Retrospective Studies Scotland Splenectomy Steroids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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