| Idiopathic pulmonary hemosiderosis: Alveoli are an answer to anemia. | |
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MedLine Citation:
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PMID: 21206122 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder (triad of iron-deficiency anemia, hemoptysis, and alveolar infiltrates). A 3-year-old male presented with mild fever, breathlessness, dry cough, and bluish nail discoloration for 8 days. He had required five blood transfusions in the past 1 year (last transfusion was given 4 months ago). He had a respiratory rate of 58/min with respiratory distress, cyanosis, and grade III clubbing. Respiratory system examination was normal. Several previous reports of hemoglobin were as low as 3.6 g/dl with hypochromic and microcytic anemia. There were transient increases in the hemoglobin and normalization of red cell morphology with blood transfusions. Serum iron, G6PD enzyme assay, hemoglobin electrophoresis, the sickling test, Coomb's test, stool and urine analysis, and a Meckel's scan were normal. HIV antibody and dsDNA were negative. The chest radiograph revealed symmetrical patchy infiltrates sparing lung apices (confirmed on high-resolution computed tomography). Lung biopsy diagnosed pulmonary hemosiderosis (interstitial lung disease with hemosiderin-laden macrophages scattered in the alveoli and areas of fibrosis in the alveolar septa). The patient showed marked clinical improvement in 10 days of therapy with prednisolone. IPH should be listed in the differential diagnosis of a child presenting with unexplained hypochromic, microcytic anemia and respiratory symptoms. |
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Authors:
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S Bhatia; M S Tullu; P Vaideeswar; K R Lahiri |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-5 |
Journal Detail:
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Title: Journal of postgraduate medicine Volume: - ISSN: 0022-3859 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985196R Medline TA: J Postgrad Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, Pediatric Chest Clinic, Seth GS Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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