Document Detail

Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure.
MedLine Citation:
PMID:  8087336     Owner:  NLM     Status:  MEDLINE    
Idiopathic pulmonary fibrosis (IPF) risk-related factors were epidemiologically investigated on the basis of 1,311 Japanese IPF autopsy cases selected from the annual complications of autopsy data records in Japan during a 12-yr period. Age and sex distribution of the subjects revealed a high peak in their seventh decade with males predominating. The IPF rate was more than two times higher (p < 0.01) among subjects engaged in occupations that exposed them to dust or organic solvents compared with those in other jobs. To ascertain job characteristics, an autopsy-case control study was conducted using other annual volumes of the autopsy data records and a similar tendency was observed. Then, a live-case control study was undertaken of 86 subjects with IPF. A significantly higher odds ratio was noted among metal production workers and miners compared with healthy and hospital control subjects (1.37 and 1.34, respectively, p < 0.01), and also a significantly lower odds ratio among subjects who frequently eat fish. Taken together with results of recent in vitro studies, the intrapulmonary deposition of hazardous dusts, especially metallic dusts, appears to play at least a partial role in initiating IPF.
K Iwai; T Mori; N Yamada; M Yamaguchi; Y Hosoda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  150     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-10-20     Completed Date:  1994-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  670-5     Citation Subset:  AIM; IM    
Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, National Institute of Health and Nutrition, Kiyose,Tokyo.
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MeSH Terms
Age Distribution
Aged, 80 and over
Autopsy / statistics & numerical data
Case-Control Studies
Chi-Square Distribution
Dust / adverse effects
Epidemiologic Methods
Japan / epidemiology
Logistic Models
Middle Aged
Occupational Exposure / adverse effects*,  statistics & numerical data
Pulmonary Fibrosis / epidemiology*,  etiology,  pathology
Sex Distribution
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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