Document Detail

Idiopathic premature ovarian failure in 63 young women.
MedLine Citation:
PMID:  16439854     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Premature ovarian failure (POF) in adolescents is defined as primary or secondary amenorrhea associated with high follicle-stimulating hormone (FSH) levels. In normal 46,XX patients, its etiology is most often unknown. We have evaluated the clinical, hormonal and ovarian phenotypes in patients with a normal karyotype who were diagnosed with POF before the age of 18. METHODS: Sixty-three patients were included in this retrospective study. RESULTS: The mean patient age was 20.4 years. The patients presented with three clinical patterns: lack of pubertal development (n = 23), primary amenorrhea with interrupted puberty (n = 18), and secondary amenorrhea with normal puberty (n = 22). Ten patients had a familial history of POF and 6 presented with hypothyroidism. The FSH, estradiol and inhibin B levels were not statistically different in the three clinical groups. Fifty percent of the patients presented small ovaries (length <2 cm) at ultrasonography. The presence of follicles was found at histology in only 7 of the 27 patients who underwent an ovarian biopsy. CONCLUSION: 46,XX patients presenting with early POF rarely presented a specific, identifiable disorder. We discuss the clinical management and different diagnosis strategies to improve our current knowledge of this syndrome.
N Massin; C Czernichow; E Thibaud; F Kuttenn; M Polak; P Touraine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-26
Journal Detail:
Title:  Hormone research     Volume:  65     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-21     Completed Date:  2006-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel
Department of Endocrinology and Reproductive Medicine, Necker-Enfants Malades Hospital, Faculty of Medicine, Paris V University, Paris, France.
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MeSH Terms
Gonadal Hormones / blood
Ovarian Failure, Premature / blood,  etiology*,  physiopathology
Ovary / physiopathology,  ultrasonography
Pituitary Hormones, Anterior / blood
Reg. No./Substance:
0/Gonadal Hormones; 0/Pituitary Hormones, Anterior

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