| Idiopathic nephrotic syndrome and atopy: is there a common link? | |
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MedLine Citation:
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PMID: 19556042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous reports during the last 60 years have reported a strong association between idiopathic nephrotic syndrome and atopic disorders. Idiopathic nephrotic syndrome can be precipitated by allergic reactions and has been associated with both aeroallergens (pollens, mold, and dust) and food allergies. Patients with idiopathic nephrotic syndrome also may show increased serum immunoglobulin E (IgE) levels. A review of the literature suggests that although some idiopathic nephrotic syndrome cases may be associated with allergies, evidence that it is a type of allergic disorder or can be induced by a specific allergen is weak. Rather, it is likely that the proteinuria and increased IgE levels in patients with idiopathic nephrotic syndrome are caused by increased levels of interleukin 13 observed in these patients. Recent studies suggest that interleukin 13, a known stimulator of IgE response, may mediate proteinuria in patients with minimal change disease because of its ability to directly induce CD80 expression on the podocyte. |
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Authors:
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Maher Abdel-Hafez; Michiko Shimada; Pui Y Lee; Richard J Johnson; Eduardo H Garin |
Publication Detail:
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Type: Journal Article; Review Date: 2009-06-25 |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 54 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2009-11-16 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 945-53 Citation Subset: IM |
Affiliation:
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Division of Pediatric Nephrology, University of Florida, Gainesville, FL 32610, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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immunology Humans Hypersensitivity, Immediate / complications* Immunoglobulin E / immunology Nephrosis, Lipoid / complications, immunology Nephrotic Syndrome / etiology*, immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK052121-13/DK/NIDDK NIH HHS; R01 HL068607-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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