Document Detail

Idiopathic myelofibrosis with prominent postsplenectomy erythroblastosis terminating in acute myeloid transformation.
MedLine Citation:
PMID:  12412736     Owner:  NLM     Status:  MEDLINE    
Idiopathic myelofibrosis is a myeloproliferative disease with poor prognosis and without sufficient therapy. Acute leukemic transformation occurs in 15% of patients. The authors report the case of a 63 year old myelofibrotic patient treated with splenectomy. During the clinical course they observed unusually prominent and persistent erythroblastosis in the peripherial blood. After a two years long, relatively stable period the disease terminated in acute myeloid leukemia.
P Tóth; Z Tóth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Haematologia     Volume:  32     ISSN:  0017-6559     ISO Abbreviation:  Haematologia (Budap)     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-06-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0130266     Medline TA:  Haematologia (Budap)     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
1st Department of Internal Medicine, County Hospital, Zala, Hungary.
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MeSH Terms
Acute Disease
Cell Transformation, Neoplastic
Erythroblasts / pathology
Leukemia, Myeloid / etiology*
Middle Aged
Neoplasm Invasiveness
Polycythemia / pathology*
Primary Myelofibrosis / blood*,  etiology,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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