| Idiopathic inflammatory myositis is associated with a high incidence of hypertension and diabetes mellitus. | |
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MedLine Citation:
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PMID: 20536597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The long-terms complications of immunosuppressive and anti-inflammatory treatment in idiopathic inflammatory myositis (IIM) are unknown. We sought to determine the complications of these treatments in a large cohort of patients with biopsy-proven IIM. METHODS: A South Australian database for patients with biopsy-proven IIM was established. Clinical details of patients including treatment received were recorded. RESULTS: Forty-three patients with dermatomyositis (DM), 184 with polymyositis (PM) and 117 with inclusion body myositis (IBM) were registered on the database. The prevalence of hypertension and diabetes in this population was 62% and 29%, respectively, considerably higher than the background prevalence of 9.4% and 4%, making detection of treatment-related adverse effects difficult. Hypertension and ischemic heart disease were more likely to be present prior to the diagnosis of IIM rather than following it. Hypertension and diabetes occurred more frequently following the diagnosis of myositis, in patients with DM compared with PM or IBM. CONCLUSIONS: We report a novel association of IIM with hypertension, diabetes and ischemic heart disease, indicating that a comprehensive assessment of vascular risk factors is essential in IIM. |
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Authors:
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Vidya S Limaye; Sue Lester; Peter Blumbergs; Peter J Roberts-Thomson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of rheumatic diseases Volume: 13 ISSN: 1756-185X ISO Abbreviation: Int J Rheum Dis Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474930 Medline TA: Int J Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 132-7 Citation Subset: IM |
Affiliation:
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Rheumatology Department, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia. Vidya.limaye@health.sa.gov.a |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Inflammatory Agents / adverse effects Comorbidity Dermatomyositis / drug therapy, epidemiology Diabetes Mellitus / epidemiology* Female Humans Hypertension / epidemiology* Immunosuppressive Agents / adverse effects Incidence Male Middle Aged Myositis / drug therapy, epidemiology* Myositis, Inclusion Body / drug therapy, epidemiology Polymyositis / drug therapy, epidemiology Risk Factors South Australia / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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