Document Detail

Idiopathic hypertrophic pachymeningitis responsive to mycophenolate.
MedLine Citation:
PMID:  22141296     Owner:  NLM     Status:  MEDLINE    
Idiopathic hypertrophic pachymeningitis (IHP) represents a rare inflammatory condition that affects the central nervous system, often difficult to treat. We report the case of a patient who presented with difficulty in swallowing, slurred speech and ataxia associated with headache, vomiting and weight loss. He was diagnosed with IHP. He deteriorated despite treatment with high dose steroids and other immunosuppressants, including pulsed cyclophosphamide. Mycophenolate mofetil was therefore administered resulting in improvement and stabilization. This is the first report in English literature of the use of mycophenolate mofetil in the treatment of IHP and could stimulate further research in its efficacy in managing this condition.
Angelos Assiotis; Marios Hadjivassiliou
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neurologica Belgica     Volume:  111     ISSN:  0300-9009     ISO Abbreviation:  Acta Neurol Belg     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-12-06     Completed Date:  2012-01-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0247035     Medline TA:  Acta Neurol Belg     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  252-4     Citation Subset:  IM    
Trauma and Orthopaedics CT2, Charing Cross Hospital, London, UK.
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MeSH Terms
Hypertrophy / immunology,  pathology
Immunosuppressive Agents / therapeutic use*
Magnetic Resonance Imaging
Meninges / immunology,  pathology
Meningitis / drug therapy*,  immunology*,  pathology
Middle Aged
Mycophenolic Acid / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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