Document Detail

Idiopathic hypertrophic pachymeningitis: Clinical, laboratory and neuroradiologic features in China.
MedLine Citation:
PMID:  24589555     Owner:  NLM     Status:  Publisher    
Hypertrophic pachymeningitis is a rare chronic inflammatory disorder characterized by marked fibrous thickening of the cerebral and/or spinal dura mater. Clinical, laboratory, neuroradiologic and therapeutic data from 12 patients with idiopathic hypertrophic pachymeningitis (IHP) from our department were retrospectively studied. There were four men and eight women with a mean age of 49±15.3years, and more than half of the patients (58%) were aged 40-60years. Headache was the most common symptom, occurring in 92% of patients. Headache improved markedly and rapidly after glucocorticoid treatment. Optic nerve involvement was noted in seven patients (58%). C-reactive protein levels increased in 80% and the erythrocyte sedimentation rate increased in 71% of patients. Three patients were positive for autoantibodies, including antinuclear antibodies (ANA), perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA), anti-cardiolipin antibodies (ACA) and rheumatoid factor (RF). Cerebrospinal fluid showed inflammatory changes, and protein levels were low to moderately elevated. MRI revealed a thickened dura in all patients, and five patients (42%) were diagnosed with sinus stenosis/occlusion. IHP is a chronic inflammatory disorder of the dura with three groups of symptoms, namely headache, cranial nerve palsy and symptoms due to sinus stenosis/occlusion. However, IHP has different features in China in that it predominantly affects women and the age of onset is younger. Sinus stenosis/occlusion is relatively common in IHP patients in China.
Mangsuo Zhao; Tongchao Geng; Liyan Qiao; Jie Shi; Jinghui Xie; Fangjie Huang; Xianzhong Lin; Jing Wang; Huancong Zuo
Related Documents :
23740665 - Il6 as an inflammatory mediator and target of therapy in chronic periaortitis.
24858965 - Changes of procalcitonin level in multiple trauma patients.
24976995 - Vaspin and lipocalin-2 levels in severe obsructive sleep apnea.
24567895 - Cerebral macroabscess caused by candida albicans in an immunocompetent patient: a diagn...
22940405 - Nonmalignant cutaneous findings associated with vemurafenib use in patients with metast...
21901255 - Driving simulation can improve insight into impaired driving skills in cirrhosis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-13
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  -     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diminished WNT -> ?-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-i...
Next Document:  Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease.