Document Detail

Idiopathic granulomatous mastitis: a 25-year experience.
MedLine Citation:
PMID:  18222379     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic inflammatory condition of the breast that can mimic inflammatory breast cancer and periductal mastitis (PDM). Eighteen patients with a histopathologic diagnosis of IGM, seen over a period of 25 years, were retrospectively reviewed and compared with 133 patients with PDM and 100 normal patients. STUDY DESIGN: The unit's pathology database and clinic letters for this time period were used to identify patients who had presented with IGM. A retrospective review of the notes was used to extract reproductive factors, cigarette smoking habits, and ethnicities that were recorded at presentation. These were compared with data from a similar group of patients with PDM and a control group. RESULTS: All IGM patients were women. Median age was 36 years (range 18 to 67 years) compared with 52 years (range 20 to 77 years) for PDM patients (p < 0.001). Seventeen percent of IGM patients were smokers at the time of presentation, as compared with 60% of PDM patients (p < 0.001). Although parity was similar for all groups, 10 IGM patients (56%) had given birth in the last 5 years, compared with 6 (5%) PDM patients (p < 0.001) and 20 (20%) in the control group (p=0.0194). Two IGM patients had recurrences after pregnancy. The course of IGM varied from 11 to 105 weeks and was not affected by any treatment modalities. CONCLUSIONS: IGM patients are younger, have given birth more recently, and are less likely to be Caucasian as compared with PDM patients. IGM is not related to smoking and can recur. Treatment should be supportive.
Bilal Al-Khaffaf; Fiona Knox; Nigel J Bundred
Related Documents :
7749879 - Association between circulating immune complexes, complement c4 null alleles, and myoca...
2465679 - Parietaria judaica and dermo-respiratory allergy in barcelona: a study of 250 cases.
68089 - Immunologic studies in pneumococcal disease.
8383189 - Clinical, neurophysiological and immunological evidence of polyneuropathy in patients w...
6086249 - Humoral and cellular immunity in patients with nasopharyngeal carcinoma.
1449249 - Electron transfer complex i defect in idiopathic dystonia.
1364169 - Does c-reactive protein modulate t-lymphocyte function in methotrexate-treated rheumato...
17873759 - Clinical significance of thyroid disease in patients with inflammatory myopathy.
9345439 - Acute unilateral papillitis versus retrobulbar neuritis: relation to multiple sclerosis.
Publication Detail:
Type:  Journal Article     Date:  2007-10-29
Journal Detail:
Title:  Journal of the American College of Surgeons     Volume:  206     ISSN:  1879-1190     ISO Abbreviation:  J. Am. Coll. Surg.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-02-14     Revised Date:  2009-05-21    
Medline Journal Info:
Nlm Unique ID:  9431305     Medline TA:  J Am Coll Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  AIM; IM    
Department of Academic Surgery, Wythenshawe Hospital, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Case-Control Studies
Cohort Studies
Ethnic Groups / statistics & numerical data*
Life Style
Mastitis / diagnosis,  epidemiology*,  therapy
Middle Aged
Reproductive History*
Risk Factors
Smoking / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Significance of sentinel lymph node micrometastases in human breast cancer.
Next Document:  Predictors of breast asymmetry after breast-conserving operation for breast cancer.