Document Detail


Idiopathic granulomatous lobular mastitis - report of 43 cases from iran; introducing a preliminary clinical practice guideline.
MedLine Citation:
PMID:  24550752     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We aimed to report a large series of idiopathic granulomatous lobular mastitis (IGLM) from Iran and sketch preliminary clinical practice guidelines (CPG) for approaching an inflammatory breast mass.
PATIENTS AND METHODS: In a retrospective records review, 43 consecutive IGLM cases were studied. Data on baseline, clinical, imaging, and pathologic characteristics were collected.
RESULTS: The mean age of the women was 33.5 years. All but 1 were married and had given birth. 16% had a cancer-like presentation. Inflammatory signs, architectural distortion, and a nodular pattern were the most common findings clinically, mammographically and ultrasonographically, respectively. 29.5% of the pathological reports indicated necrosis which was more common in younger subjects (p = 0.016); microabscesses were associated with a shorter lactation course (p = 0.006). Corticosteroids had been used as the initial treatment modality in 51%, immunosuppressive agents had not been administered, and a 16% relapse rate was recorded. We recognized the need for a multidisciplinary approach covering radiology, oncology, and surgery to best handle diagnostic and therapeutic issues and manage relevant infections as well as the major differential diagnosis, i.e. malignancy.
CONCLUSION: We hypothesized that a shorter lactation period may cause more milk stasis and extravasation and be contributory to IGLM. CPGs are needed to incorporate the needed multidisciplinary approach and to standardize IGLM care. We present one such guideline.
Abstract available from the publisher.
Authors:
Ramesh Omranipour; S-Farzad Mohammadi; Parisa Samimi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Breast care (Basel, Switzerland)     Volume:  8     ISSN:  1661-3791     ISO Abbreviation:  Breast Care (Basel)     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-02-19     Completed Date:  2014-02-19     Revised Date:  2014-02-21    
Medline Journal Info:
Nlm Unique ID:  101254060     Medline TA:  Breast Care (Basel)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  439-43     Citation Subset:  -    
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