Document Detail

Idiopathic generalized sebaceous gland hyperplasia of the Border terrier: a morphometric study.
MedLine Citation:
PMID:  20500498     Owner:  NLM     Status:  In-Process    
Skin biopsies from five Border terriers with histologically confirmed idiopathic, generalized sebaceous gland hyperplasia (Group A) were compared morphometrically to those from four unaffected Border terriers (Group B) and the unaffected dogs to biopsies from four other terrier breeds (Group C). Dogs in Group A had significantly higher numbers of sebaceous gland lobules per hair follicle than those in Group B (P=0.020) but there was no significant difference between Groups B and C. The total sebaceous gland lobular area per hair follicle was significantly higher in dogs in Group A than Group B (P=0.020) but there were no differences between Groups B and C. There were no significant differences in the size of the individual sebaceous gland lobules. There were no significant differences in the total number of basal or mature sebocytes between Groups A and B but significantly lower numbers of both cell types were seen in Group C compared to Group B. There were significantly more basal sebaceous cells undergoing mitosis in dogs in Group A than Group B (P=0.017) but no significant difference between Groups B and C. These results indicate that the physical signs of sebaceous gland hyperplasia are caused by an increase in the number of sebaceous gland lobules and total lobular area. Border terriers may be genetically predisposed to the development of idiopathic generalized sebaceous gland hyperplasia compared with other dog breeds but also to sebaceous gland hyperplasia secondary to other dermatopathies.
Carla Dedola; Lorenzo Ressel; Peter B Hill; Adri H M Van Den Broek; Keith L Thoday
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-24
Journal Detail:
Title:  Veterinary dermatology     Volume:  21     ISSN:  1365-3164     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  494-502     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal compilation © 2010 ESVD and ACVD.
The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Dermatology Group, Division of Veterinary Clinical Sciences, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.
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