| Idiopathic erythrocytosis, diagnosis and clinical management. | |
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MedLine Citation:
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PMID: 11317965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By definition, idiopathic erythrocytosis (IE) applies to a group of patients characterised by having a measured RCM above their predicted normal range (an absolute erythrocytosis) and following investigation do not have a form of primary or secondary erythrocytosis. Patients with IE are heterogenous. The possibilities include physiological variation, 'early' polycythaemia vera (10-15% develop clear features of PV over a few years), unrecognized congenital erythrocytosis, unrecognized or unrecognizable secondary acquired erythrocytosis or a currently undescribed form of primary or secondary erythrocytosis. Patients are more commonly male with a median age at presentation of 55-60 years. Approximately half of the patients present with vascular occlusive complications. Retrospective evidence indicates that vascular occlusion occurs less frequently when the PCV is controlled at normal levels. Venesection is the treatment of choice to lower the PCV. As a general approach to management, all patients with a PCV above 0.54 should be venesected to a PCV less than 0.45. This target PCV should also apply to patients with lesser degrees of raised PCV who have additional other risk factors for vascular occlusion. |
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Authors:
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T C Pearson; M Messinezy |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pathologie-biologie Volume: 49 ISSN: 0369-8114 ISO Abbreviation: Pathol. Biol. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-24 Completed Date: 2001-06-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0265365 Medline TA: Pathol Biol (Paris) Country: France |
Other Details:
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Languages: eng Pagination: 170-7 Citation Subset: IM |
Affiliation:
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Department of Haematological Medicine, Guy's, King's and St Thomas' School of Medicine, St Thomas' Hospital, London SE1 7EH, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anoxia / complications Arterial Occlusive Diseases / etiology Bone Marrow / pathology Chlorambucil / adverse effects, therapeutic use Diagnosis, Differential Endocrine System Diseases / complications Erythrocyte Volume Erythroid Precursor Cells / pathology Erythropoietin / blood Genetic Predisposition to Disease Humans Kidney Diseases / complications Leukemia / chemically induced Leukemia, Radiation-Induced / etiology Middle Aged Phosphorus Radioisotopes / adverse effects, therapeutic use Polycythemia* / classification, congenital, diagnosis, etiology, therapy Polycythemia Vera / diagnosis Receptors, Erythropoietin / deficiency, genetics Sequence Deletion Smoking / blood Stroke / etiology |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Radioisotopes; 0/Receptors, Erythropoietin; 11096-26-7/Erythropoietin; 305-03-3/Chlorambucil |
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