Document Detail

Idiopathic eosinophilia associated with portal vein and massive thrombosis: successful thrombolysis with streptokinase.
MedLine Citation:
PMID:  16733488     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Portal vein thrombosis in adults is usually related to cirrhosis. There are several possible therapies. including anticoagulation, transjugular intrahepatic portosystemic shunt, balloon dilatation, local and systemic fibrinolytics agents. Hypercoagulable states are also reported in association with this disease entity. Eosinophilia may activate platelets and promote thrombosis due to proteins contained in intracytoplasmic granules, such as eosinophil cationic protein and major basic protein. There is only one paper in the medical literature linking eosinophilia and portal vein thrombosis. CASE REPORT: We present here the case of a middle-age woman with idiopathic eosinophilia and acute portal vein thrombosis with massive venous thrombosis, involving the mesenteric, splenic, inferior cava, iliac and femoral veins, successfully treated with systemic streptokinase. CONCLUSIONS: Acute portal vein thrombosis with associated mesenteric and splenic vein thrombosis is a potentially lethal coagulation disorder that can be treated successfully with systemic streptokinase.
Jesús Monterrubio Villar; Alberto Córdoba López; Anselmo J Macayo Sánchez
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-29
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  12     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-08-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CS53-6     Citation Subset:  IM    
Intensive Care Unit, Hospital Don Benito-Villanueva, Badajoz, Spain.
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MeSH Terms
Budd-Chiari Syndrome / drug therapy*,  etiology,  radiography*
Eosinophilia / complications
Middle Aged
Portal Vein / pathology*
Streptokinase / therapeutic use*
Thrombolytic Therapy*
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
EC 3.4.-/Streptokinase

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