Document Detail

Idiopathic cardiomyopathy, age, and suppressor-cell dysfunction as risk determinants of lymphoma after cardiac transplantation.
MedLine Citation:
PMID:  82142     Owner:  NLM     Status:  MEDLINE    
A review of lymphomas developing in recipients of cardiac allografts has yielded significant risk factors. Frequency varied strikingly according to original cardiac disease: lymphoma developed in 6 of 37 patients with prior idiopathic cardiomyopathy (I.C.M.) but in one of 54 patients with prior coronary-artery disease (C.A.D.). All patients who developed lymphomas were aged under 40. Combination of both risk factors (I.C.M. and age less than 40) produces a sub-group with a highly significantly increased risk of lymphoma. I.C.M., but not C.A.D., is characterised by a defect in mitogen-induced mononuclear-cell suppressor activity. It is postulated that defective regulation in the immune systems of younger patients under chronic alloantigen stimulation may allow lymphoid proliferation to proceed to lymphoreticular malignancy. Immunosuppressive agents such as azathioprine may exert a co-oncogenic effect.
J L Anderson; R E Fowles; C P Bieber; E B Stinson
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-01-26     Completed Date:  1979-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1174-7     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Cardiomyopathies / complications*
Heart Transplantation*
Immunologic Deficiency Syndromes / complications*
Lymphocyte Activation
Lymphoma / epidemiology,  etiology*
Lymphoma, Large B-Cell, Diffuse / etiology
Postoperative Complications / etiology*
T-Lymphocytes / immunology*
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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