Document Detail

Idiopathic arterial calcification of infancy: effectiveness of prostaglandin infusion for treatment of secondary hypertension refractory to conventional therapy: case report.
MedLine Citation:
PMID:  8960499     Owner:  NLM     Status:  MEDLINE    
A premature baby had severe hypertension associated with idiopathic arterial calcification of infancy. Despite the fact that there was laboratory evidence of renin-mediated hypertension, the disease was refractory to specific renin antagonist and failed to respond to conventional medical treatment. Prostaglandin E1 (PGE1) infusion (dosage range 0.017-0.068 microgram/kg/min) promptly controlled hypertension on two occasions. The drug was given for a total of 65 days and then stopped after the appearance of severe thrombocytopenia; other side effects included sporadic hyperthermia and irritability. Blood pressure was then stabilized satisfactory by a multiple-antihypertensive regimen. In the light of these findings, we believe that PGE1 infusion is a possible therapeutic alternative for babies with idiopathic arterial calcification complicated by severe hypertension refractory to conventional treatment.
G Ciana; F Colonna; V Forleo; F Brizzi; A Benettoni; U de Vonderweid
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  18     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Neonatology Center, Istituto per l'Infanzia, Burlo Garofolo, Trieste, Italy.
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MeSH Terms
Calcinosis / complications*
Hypertension / drug therapy*,  etiology
Infant, Newborn
Infant, Premature
Prostaglandins E / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Prostaglandins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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