| Idiopathic acute eosinophilic pneumonia: a study of 22 patients. | |
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MedLine Citation:
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PMID: 12403693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic acute eosinophilic pneumonia (IAEP) is characterized by acute febrile respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia. We conducted a multicenter retrospective study to characterize this rare clinical entity further and to improve its diagnostic criteria. A total of 13 male and 9 female patients (mean age: 29 +/- 15.8 years) presented with severe hypoxemia (Pa(O2)/fraction of inspired oxygen ratio = 156 +/- 74.1) requiring mechanical ventilation in 14 cases. Bronchoalveolar lavage was performed on all patients and showed 54.4 +/- 19.2% eosinophils on differential cell count, but no open-lung biopsies were done. No clinical differences were found between patients seen at less than 7 days (n = 15) or at 7 to 31 days (n = 7) from the onset of IAEP. A total of 12 patients met the clinical criteria of acute lung injury, and eight of these patients met the criteria for acute respiratory distress syndrome. All patients recovered, either spontaneously (6) or on corticosteroid treatment (16). No relapses occurred. We conclude that: (1) diagnostic criteria of IAEP are compatible with a duration of symptoms for up to 1 month, but the response to corticosteroid treatment is not diagnostic because of possible spontaneous recovery; (2) IAEP should be considered as differential diagnosis of acute lung injury or acute respiratory distress syndrome; (3) bronchoalveolar lavage eosinophilia obviates the need for lung biopsy in IAEP. |
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Authors:
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François Philit; Bénédicte Etienne-Mastroïanni; Antoine Parrot; Claude Guérin; Dominique Robert; Jean-François Cordier |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 166 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-29 Completed Date: 2002-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1235-9 Citation Subset: AIM; IM |
Affiliation:
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Service d'Assistance Respiratoire et Réanimation Médicale, Hôpital de la Croix Rousse, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Aged, 80 and over Diagnosis, Differential Female Humans Male Middle Aged Pulmonary Eosinophilia / blood*, radiography*, therapy Retrospective Studies Time Factors Tomography, X-Ray Computed |
| Comments/Corrections | |
Comment In:
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Am J Respir Crit Care Med. 2002 Nov 1;166(9):1157-8
[PMID:
12403684
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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