Document Detail

Idiopathic acquired generalized anhidrosis due to occlusion of proximal coiled ducts.
MedLine Citation:
PMID:  15030348     Owner:  NLM     Status:  MEDLINE    
Idiopathic acquired generalized anhidrosis is a very rare disease of unknown pathogenesis. We report a 25-year-old man with acquired generalized anhidrosis due to occlusion of the coiled ducts. He did not have sweat secretion over the entire surface of the body, including the palms and soles. Sweat-inducing stimuli provoked tingling pain on the skin. Pilocarpine iontophoresis on the forearm did not induce sweat secretion. Neurological examination did not reveal any abnormality in the central or peripheral nervous system. Skin biopsy showed that the coiled ducts were occluded by an amorphous eosinophilic substance. This amorphous eosinophilic substance was positive with periodic acid-Schiff (PAS) staining and was resistant to digestion by diastase. Electron microscopy demonstrated that the coiled ducts were completely occluded by an amorphous substance. The substance occluding the coiled ducts contained fibrous structures. These findings suggested that the acquired generalized anhidrosis in this patient was caused by occlusion of the coiled ducts by a PAS-positive substance probably derived from dark cell granules.
J Ogino; K Saga; M Kagaya; A Kamada; R Kaneko; K Jimbow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  150     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-19     Completed Date:  2004-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  589-93     Citation Subset:  IM    
Department of Dermatology, Sapporo Medical University School of Medicine, Chyuo-ku, Minami 1, Nishi 16, Sapporo, Japan.
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MeSH Terms
Cytoplasm / pathology
Eosinophils / pathology
Hypohidrosis / drug therapy,  etiology*,  pathology
Microscopy, Electron
Skin / pathology
Sweat Glands / pathology
Sweating / physiology

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