Document Detail

Idiopathic Ventricular Fibrillation, Early Repolarization and Other J Wave-Related Ventricular Fibrillation Syndromes.
MedLine Citation:
PMID:  23131759     Owner:  NLM     Status:  Publisher    
Current clinical and experimental data demonstrate that the electrocardiographic J wave plays a critical role in the pathogenesis of ventricular fibrillation (VF) in patients with Brugada syndrome (BS) and early repolarization (ER) syndrome (ERS). This has generated renewed interest in the presence of J waves and ERS in the general population, yet the identification of high-risk ECG markers and the risk stratification of subjects with ERS remain to be established. More recently, this concept has been expanded to VF mechanisms in patients with structural heart diseases. Some of the fatal arrhythmias in the setting of acute myocardial ischemia or infarction may share a similar, J wave-related electrophysiologic process. In canine arterially perfused wedge preparations, the occurrence of J wave-related arrhythmias is mediated by phase 2 reentry. The stability of the action potential (AP) dome in the ventricular epicardium is dependent on the prominence of the AP phase 1 notch. The ability to maintain the AP dome depends on a delicate balance between inward and outward ionic currents during depolarization and the early phase of repolarization. Outward shifts of the balance and inability to maintain the AP dome result in marked dispersion of repolarization and vulnerability to VF. This review describes the electrocardiographic and clinical features of the J waves in idiopathic VF and other structural heart diseases.
Gi-Byoung Nam
Related Documents :
24585939 - Coronary spasm and myocardial bridging: an elusive pathophysiological mechanism leading...
1857119 - Measurement of left ventricular heat production in man.
198179 - Some myocardial factors of biological oxidation in experimental myocardial infarction.
9757139 - Adaptive changes in the capillary network in the left ventricle of rat heart.
15210449 - Endocardial endothelium in the avascular frog heart: role for diffusion of no in contro...
15173699 - The pulmonary artery catheter in critically ill patients. does it change outcome?
7572689 - Reduction in coronary events during treatment with pravastatin. plac i and plac ii inve...
11174339 - Evidence of cardiac myolysis in severe nonischemic heart failure and the potential role...
15670969 - Electrical characteristics of low atrial septum pacing compared with right atrial appen...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-07
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Asan Medical Center, Department of Internal Medicine, University of Ulsan College of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal gan...
Next Document:  Preparation and evaluation of C(10)-cationic latex particle coated open-tubular column for capillary...