| Idiopathic Duct-Centric Pancreatitis: Disease Description and Endoscopic Ultrasonography-Guided Trucut Biopsy Diagnosis. | |
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MedLine Citation:
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PMID: 21525775 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/Aims: Recent data demonstrate the presence of two autoimmune pancreatitis (AIP) subtypes. All existing endoscopic ultrasonography-guided trucut biopsy (EUS-TCB) data pertain to type 1 disease. Our aim is to determine if EUS-TCB samples are sufficient for diagnosing type 2 AIP. Methods: This is a retrospective case series conducted in an academic tertiary care center. Patients included those with type 2 AIP (n = 5), retrospectively identified from a database of all patients with AIP, diagnosed by HISORt criteria (n = 125). The primary outcome measure was the diagnostic capability of EUS-TCB for type 2 AIP. Results: 5 patients (4 male, 1 female; mean age 39.6 years) who underwent EUS-TCB were diagnosed with type 2 AIP. The serum IgG(4) level was elevated in 1 of the 4 patients tested. CT/MRI revealed diffuse pancreas enlargement (n = 3), a pancreas head mass (n = 1), and a normal pancreas (n = 1). Prior to EUS, AIP was not specifically suspected, but part of a broad differential (n = 3) or not suspected at all (n = 2). Fine-needle aspiration was negative for neoplasia and AIP. The TCB histology was definitive (n = 4) or suggestive (n = 1) for type 2 AIP. No complications developed. Conclusions: EUS-TCB may be safe and may provide sufficient material to definitively diagnose type 2 AIP. and IAP. |
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Authors:
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Michael J Levy; Thomas C Smyrk; Naoki Takahashi; Lizhi Zhang; Suresh T Chari |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-27 |
Journal Detail:
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Title: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Volume: 11 ISSN: 1424-3911 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966936 Medline TA: Pancreatology Country: - |
Other Details:
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Languages: ENG Pagination: 76-80 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minn., USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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