| Identifying tremor-related characteristics of basal ganglia nuclei during movement in the Parkinsonian patient. | |
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MedLine Citation:
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PMID: 20884273 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Local field potential (LFP) and Electromyographic (EMG) signals were recorded from 12 Parkinsonian patients with tremor-dominant symptoms as they performed passive and voluntary movements. The LFP signals were categorised into episodes of tremorous and atremorous activity (identified through EMG power spectra), then divided into delta (2-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) frequency bands. Modulation of LFP oscillatory activity in these frequency bands were compared between the subthalamic nucleus (STN) and the globus pallidus internus (GPi) to determine if differential tremor-related characteristics were identifiable for either target. Our results suggest that such local characteristic activity is identifiable in the STN, and thus could be a target for initial development of a closed-loop demand driven stimulator device which capitalises on such activity to trigger stimulation, even during voluntary movement activity. |
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Authors:
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Jonathan G Burgess; Kevin Warwick; Virginie Ruiz; Mark N Gasson; Tipu Z Aziz; John-Stuart Brittain; John Stein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-29 |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: 16 ISSN: 1873-5126 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
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Languages: eng Pagination: 671-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Systems Engineering, University of Reading, UK. j.g.burgess@reading.ac.uk |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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WT 088877/Z/09/Z//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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