| Identifying traumatic brain injury in patients with isolated head trauma: are arterial lactate and base deficit as helpful as in polytrauma? | |
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MedLine Citation:
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PMID: 17452699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increase in lactate (LAC) within the central nervous system after head trauma is an established marker of traumatic brain injury (TBI). OBJECTIVE: To investigate the utility of arterial base deficit (BD) and LAC in identifying TBI in patients with isolated head injury (IHI). Materials and METHODS: TBI was defined as Glasgow Coma Scale < or =8, head Abbreviated Injury Severity Score >2 or brain haematoma on CT scan. Patients were divided into two groups: IHI with and without TBI. Data were reported as means (SDs). 131 patients with IHI were studied (mean (SD) age 39 (19) years, 78% male). RESULTS: 17% of the patients sustained TBI. The mean differences for arterial BD (0.65 mmol/l, 95% CI -0.8 to 2.1) and LAC (0.34 mmol/l, 95% CI -0.7 to 1.4) in patients with and without TBI were not significant. Analysis of receiver operating characteristic curves confirmed that arterial BD and LAC were unable to detect TBI in patients with IHI. CONCLUSION: Arterial BD and LAC are poor predictors of TBI in isolated head trauma. |
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Authors:
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Shahriar Zehtabchi; Richard Sinert; Samara Soghoian; Yiju Liu; Kristin Carmody; Lekha Shah; Mridul Kumar; Michael Lucchesi |
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Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: Emergency medicine journal : EMJ Volume: 24 ISSN: 1472-0213 ISO Abbreviation: Emerg Med J Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-06-05 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 100963089 Medline TA: Emerg Med J Country: England |
Other Details:
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Languages: eng Pagination: 333-5 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA. szehtabchi@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Imbalance
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blood* Adult Biological Markers / blood Brain Injuries / blood*, diagnosis* Cohort Studies Female Humans Lactic Acid / blood* Male Predictive Value of Tests Prospective Studies ROC Curve |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-21-5/Lactic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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