Document Detail

Identifying traumatic brain injury in patients with isolated head trauma: are arterial lactate and base deficit as helpful as in polytrauma?
MedLine Citation:
PMID:  17452699     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increase in lactate (LAC) within the central nervous system after head trauma is an established marker of traumatic brain injury (TBI).
OBJECTIVE: To investigate the utility of arterial base deficit (BD) and LAC in identifying TBI in patients with isolated head injury (IHI).
MATERIALS AND METHODS: TBI was defined as Glasgow Coma Scale < or =8, head Abbreviated Injury Severity Score >2 or brain haematoma on CT scan. Patients were divided into two groups: IHI with and without TBI. Data were reported as means (SDs). 131 patients with IHI were studied (mean (SD) age 39 (19) years, 78% male).
RESULTS: 17% of the patients sustained TBI. The mean differences for arterial BD (0.65 mmol/l, 95% CI -0.8 to 2.1) and LAC (0.34 mmol/l, 95% CI -0.7 to 1.4) in patients with and without TBI were not significant. Analysis of receiver operating characteristic curves confirmed that arterial BD and LAC were unable to detect TBI in patients with IHI.
CONCLUSION: Arterial BD and LAC are poor predictors of TBI in isolated head trauma.
Shahriar Zehtabchi; Richard Sinert; Samara Soghoian; Yiju Liu; Kristin Carmody; Lekha Shah; Mridul Kumar; Michael Lucchesi
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Emergency medicine journal : EMJ     Volume:  24     ISSN:  1472-0213     ISO Abbreviation:  Emerg Med J     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-05     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  100963089     Medline TA:  Emerg Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-5     Citation Subset:  IM    
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MeSH Terms
Acid-Base Imbalance / blood*
Biological Markers / blood
Brain Injuries / blood*,  diagnosis*
Cohort Studies
Lactic Acid / blood*
Predictive Value of Tests
Prospective Studies
ROC Curve
Reg. No./Substance:
0/Biological Markers; 33X04XA5AT/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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