Document Detail


Identifying the targets for treatment of liver fibrosis and hepatocellular carcinoma from both Western medicine and Chinese medicine.
MedLine Citation:
PMID:  22457133     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Liver fibrosis and hepatocellular carcinoma (HCC) are emerging health problems worldwide. Number of death due to HCC was steadily increased during the last decade. Although liver fibrosis and HCC have been investigated extensively, there are no successful and/or satisfactory therapies especially for patients with HCC. From our understanding of both Western medicine and Chinese medicine, it could identify the targets in liver fibrosis and HCC for intervention with Chinese medicine such as bone morphogenetic protein 4 (BMP-4). BMP-4 expression was significantly increased in both liver fibrosis and HCC and saponin class of certain Chinese herbs could regulate its expression. Therefore, BMP-4 could be one of the targets for treatment of liver fibrosis and HCC from integrative medicine.
Authors:
Yuewen Gong
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Publication Detail:
Type:  Journal Article     Date:  2012-03-30
Journal Detail:
Title:  Chinese journal of integrative medicine     Volume:  18     ISSN:  1672-0415     ISO Abbreviation:  Chin J Integr Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181180     Medline TA:  Chin J Integr Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Affiliation:
Faculties of Pharmacy and Medicine, University of Manitoba, 750 McDermot Avenue Winnipeg, Manitoba, Canada, R3E 0T5, ygong@cc.umanitoba.ca.
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