Document Detail

Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach.
MedLine Citation:
PMID:  11074017     Owner:  NLM     Status:  MEDLINE    
We have used methamphetamine treatment of rats as an animal model for psychotic mania. Specific brain regions were analyzed comprehensively for changes in gene expression using oligonucleotide GeneChip microarrays. The data was cross-matched against human genomic loci associated with either bipolar disorder or schizophrenia. Using this convergent approach, we have identified several novel candidate genes (e.g., signal transduction molecules, transcription factors, metabolic enzymes) that may be involved in the pathogenesis of mood disorders and psychosis. Furthermore, for one of these genes, G protein-coupled receptor kinase 3 (GRK3), we found by Western blot analysis evidence for decreased protein levels in a subset of patient lymphoblastoid cell lines that correlated with disease severity. Finally, the classification of these candidate genes into two prototypical categories, psychogenes and psychosis-suppressor genes, is described.
A B Niculescu; D S Segal; R Kuczenski; T Barrett; R L Hauger; J R Kelsoe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2000-11-09
Journal Detail:
Title:  Physiological genomics     Volume:  4     ISSN:  1531-2267     ISO Abbreviation:  Physiol. Genomics     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2001-02-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
Department of Psychiatry, School of Medicine, University of California, San Diego, USA.
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MeSH Terms
Bipolar Disorder / enzymology,  genetics*,  metabolism
Caenorhabditis elegans Proteins*
Farnesyl-Diphosphate Farnesyltransferase / genetics
G-Protein-Coupled Receptor Kinase 3
Genomics / methods*
Helminth Proteins / genetics
Insulin-Like Growth Factor I / genetics
Membrane Proteins / genetics
Nerve Tissue Proteins / genetics
Oxidoreductases / genetics
Protein-Serine-Threonine Kinases / genetics
Psychotic Disorders / enzymology,  genetics*,  metabolism
Rats, Sprague-Dawley
Schizophrenia / enzymology,  genetics,  metabolism
Sequence Homology, Amino Acid
Signal Transduction / genetics
Sulfotransferases / genetics
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Helminth Proteins; 0/LIN-7 protein, C elegans; 0/LIN-7 protein, mammalian; 0/LIN7A protein, human; 0/LIN7C protein, human; 0/Membrane Proteins; 0/Nerve Tissue Proteins; 67763-96-6/Insulin-Like Growth Factor I; EC 1.-/Oxidoreductases; EC Farnesyltransferase; EC Kinases; EC protein, human; EC protein, rat; EC Receptor Kinase 3; EC 2.8.2.-/Sulfotransferases; EC; EC protein, human

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