Document Detail

Identifying and managing cow's milk protein allergy.
MedLine Citation:
PMID:  20688848     Owner:  NLM     Status:  MEDLINE    
Cow's milk protein (CMP) is usually one of the first complementary foods to be introduced into the infant's diet and is commonly consumed throughout childhood as part of a balanced diet. CMP is capable of inducing a multitude of adverse reactions in children, which may involve organs like the skin, gastrointestinal (GI) tract or respiratory system. The diagnosis of CMP-induced adverse reactions requires an understanding of their classification and immunological basis as well as the strengths and limitations of diagnostic modalities. In addition to the well-recognised, immediate-onset IgE-mediated allergies, there is increasing evidence to support the role of CMP-induced allergy in a spectrum of delayed-onset disorders ranging from GI symptoms to chronic eczema. The mainstay of treatment is avoidance of CMP; this requires dietetic input to ensure that this does not lead to any nutritional compromise. This review is intended to highlight the broad spectrum of manifestations of CMP allergy and to offer an approach to the diagnosis and treatment thereof.
George du Toit; Rosan Meyer; Neil Shah; Ralf G Heine; Michael A Thomson; Gideon Lack; Adam T Fox
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-05
Journal Detail:
Title:  Archives of disease in childhood. Education and practice edition     Volume:  95     ISSN:  1743-0593     ISO Abbreviation:  Arch Dis Child Educ Pract Ed     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101220684     Medline TA:  Arch Dis Child Educ Pract Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-44     Citation Subset:  IM    
King’s College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Allergy and Lung Biology, Guy’s and St Thomas’ NHS Foundation Trust, UK.
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MeSH Terms
Milk Hypersensitivity / diagnosis*,  immunology,  therapy*
Milk Proteins / adverse effects*,  immunology
Pediatrics / methods,  standards*
Practice Guidelines as Topic
Reg. No./Substance:
0/Milk Proteins

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