Document Detail


Identifying the evolutionary building blocks of the cardiac conduction system.
MedLine Citation:
PMID:  22984480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endothermic state of mammals and birds requires high heart rates to accommodate the high rates of oxygen consumption. These high heart rates are driven by very similar conduction systems consisting of an atrioventricular node that slows the electrical impulse and a His-Purkinje system that efficiently activates the ventricular chambers. While ectothermic vertebrates have similar contraction patterns, they do not possess anatomical evidence for a conduction system. This lack amongst extant ectotherms is surprising because mammals and birds evolved independently from reptile-like ancestors. Using conserved genetic markers, we found that the conduction system design of lizard (Anolis carolinensis and A. sagrei), frog (Xenopus laevis) and zebrafish (Danio rerio) adults is strikingly similar to that of embryos of mammals (mouse Mus musculus, and man) and chicken (Gallus gallus). Thus, in ectothermic adults, the slow conducting atrioventricular canal muscle is present, no fibrous insulating plane is formed, and the spongy ventricle serves the dual purpose of conduction and contraction. Optical mapping showed base-to-apex activation of the ventricles of the ectothermic animals, similar to the activation pattern of mammalian and avian embryonic ventricles and to the His-Purkinje systems of the formed hearts. Mammalian and avian ventricles uniquely develop thick compact walls and septum and, hence, form a discrete ventricular conduction system from the embryonic spongy ventricle. Our study uncovers the evolutionary building plan of heart and indicates that the building blocks of the conduction system of adult ectothermic vertebrates and embryos of endotherms are similar.
Authors:
Bjarke Jensen; Bastiaan J D Boukens; Alex V Postma; Quinn D Gunst; Maurice J B van den Hoff; Antoon F M Moorman; Tobias Wang; Vincent M Christoffels
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-11
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-17     Completed Date:  2013-03-12     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44231     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Embryology & Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrioventricular Node / anatomy & histology,  embryology
Biological Evolution*
Gene Expression Regulation, Developmental
Heart Conduction System / anatomy & histology,  embryology*,  metabolism,  ultrasonography
Heart Ventricles / anatomy & histology,  embryology,  metabolism
Humans
Imaging, Three-Dimensional
Lizards / embryology,  genetics
Models, Biological
Phenotype
T-Box Domain Proteins / genetics,  metabolism
Xenopus / embryology,  genetics
Zebrafish / embryology,  genetics
Chemical
Reg. No./Substance:
0/T-Box Domain Protein 2; 0/T-Box Domain Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.
Next Document:  Polar/Ionizable residues in transmembrane segments: effects on helix-helix packing.