| Identifying cell cycle regulators and combinatorial interactions among transcription factors with microarray data and ChIP-chip data. | |
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MedLine Citation:
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PMID: 19887337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this paper, we integrate transcriptional regulatory modelling with temporal correlation analysis between one Transcription Factor (TF) and its corresponding cell cycle-regulated targets to investigate Cell Cycle Regulators (CCRs) and combinatorial interactions among TFs across the cell cycle in Saccharomyces cerevisiae. Our method is developed based on the rationale that if one TF or one TF combinatorial interaction takes more possibilities of sharing common cell cycle-regulated targets with other TFs, this TF or TF combinatorial interaction is more likely to control the cell cycle. Our results reveal abundant CCRs and TF co-operativities supported by biological experiments or other computational methods. |
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Authors:
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Ting Chen; Feng Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of bioinformatics research and applications Volume: 5 ISSN: 1744-5485 ISO Abbreviation: - Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101253758 Medline TA: Int J Bioinform Res Appl Country: Switzerland |
Other Details:
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Languages: eng Pagination: 625-46 Citation Subset: IM |
Affiliation:
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Department of Electronic Engineering, Fudan University, Shanghai 200433, China. Ting.Chen.lrx@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle* Chromatin Immunoprecipitation Oligonucleotide Array Sequence Analysis* Transcription Factors / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors |
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