Document Detail

Identifying RNA editing sites using RNA sequencing data alone.
MedLine Citation:
PMID:  23291724     Owner:  NLM     Status:  MEDLINE    
We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding events. We also found that human genes harboring conserved editing sites within Alu repeats are enriched for neuronal functions.
Gokul Ramaswami; Rui Zhang; Robert Piskol; Liam P Keegan; Patricia Deng; Mary A O'Connell; Jin Billy Li
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-06
Journal Detail:
Title:  Nature methods     Volume:  10     ISSN:  1548-7105     ISO Abbreviation:  Nat. Methods     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-30     Completed Date:  2013-03-28     Revised Date:  2013-08-09    
Medline Journal Info:
Nlm Unique ID:  101215604     Medline TA:  Nat Methods     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-32     Citation Subset:  IM    
Department of Genetics, Stanford University, Stanford, California, USA.
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MeSH Terms
Adenosine / genetics
Alu Elements
Computational Biology / methods
Drosophila melanogaster / genetics
Inosine / genetics
RNA Editing*
Sequence Analysis, RNA / methods*
Grant Support
T32 HG000044/HG/NHGRI NIH HHS; //Medical Research Council
Reg. No./Substance:
58-61-7/Adenosine; 58-63-9/Inosine

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