| Identifying RNA editing sites using RNA sequencing data alone. | |
| | |
MedLine Citation:
|
PMID: 23291724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding events. We also found that human genes harboring conserved editing sites within Alu repeats are enriched for neuronal functions. |
| | |
Authors:
|
Gokul Ramaswami; Rui Zhang; Robert Piskol; Liam P Keegan; Patricia Deng; Mary A O'Connell; Jin Billy Li |
Related Documents
:
|
20156104 - Genotypic characterization of hiv type 1 env gp160 sequences from three regions in thai... 15194764 - The human immunodeficiency virus type 1 promoter contains a cata box instead of a tata ... 21520944 - Proteomics-based discovery of koranimine, a cyclic imine natural product. 11404514 - A novel recombinant marker virus assay for comparing the relative fitness of hiv-1 reve... 15581894 - Role of the n terminus in enzyme activity, stability and specificity in thermophilic es... 22740664 - Genome sequence of pseudoalteromonas flavipulchra jg1, a marine antagonistic bacterium ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2013-01-06 |
Journal Detail:
|
Title: Nature methods Volume: 10 ISSN: 1548-7105 ISO Abbreviation: Nat. Methods Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-30 Completed Date: 2013-03-28 Revised Date: 2013-04-18 |
Medline Journal Info:
|
Nlm Unique ID: 101215604 Medline TA: Nat Methods Country: United States |
Other Details:
|
Languages: eng Pagination: 128-32 Citation Subset: IM |
Affiliation:
|
Department of Genetics, Stanford University, Stanford, California, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GEO/GSE42815 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine
/
genetics Alu Elements Animals Computational Biology / methods Drosophila melanogaster / genetics Humans Inosine / genetics RNA Editing* Sequence Analysis, RNA / methods* |
| Grant Support | |
ID/Acronym/Agency:
|
T32 HG000044/HG/NHGRI NIH HHS; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
|
58-61-7/Adenosine; 58-63-9/Inosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A pharmacological organization of G protein-coupled receptors.
Next Document: Can skilled readers perform a second task in parallel? A functional connectivity MRI study.