Document Detail

Identifications of inhibitors of IgE production by human lymphocytes isolated from 'Cha Chuukanbohon Nou 6' tea leaves.
MedLine Citation:
PMID:  20355027     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tea (Camellia sinensis L.) is consumed all over the world and in especially large quantities in Japan and China, where it has been used not only as a daily beverage but also for medicinal purposes for thousands of years. Tea has been found to exhibit various bioregulatory activities, including antiallergic, anticarcinogenic, antimetastatic, antioxidative, antihypertensive, antihypercholesterolemic, anti-dental caries and antibacterial effects, and to influence intestinal flora. RESULTS: Cha Chuukanbohon Nou 6 is a tea cultivar improved by the National Institute of Vegetable and Tea Science (NIVTS) in Japan. On comparing chemical constituents of 11 varieties of tea leaves by high-performance liquid chromatography, we found two new major compounds in Cha Chuukanbohon Nou 6. Nuclear magnetic resonance spectroscopy revealed these compounds to be theogallin and 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-beta-D-glucopyranose. The two were similar in chemical structure to strictinin, an inhibitor of immunoglobulin (Ig) production. Thus their effects on the production of Igs by peripheral blood lymphocytes were tested. Both compounds, like strictinin, inhibited IgE production. CONCLUSION: The results suggest Cha Chuukanbohon Nou 6 to be the basis of an antiallergic beverage.
Daiki Honma; Motoyuki Tagashira; Tomomasa Kanda; Mari Maeda-Yamamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the science of food and agriculture     Volume:  90     ISSN:  1097-0010     ISO Abbreviation:  J. Sci. Food Agric.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376334     Medline TA:  J Sci Food Agric     Country:  England    
Other Details:
Languages:  eng     Pagination:  168-74     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Society of Chemical Industry.
Research Laboratory for Health and Gustatory Science, Asahi Breweries Ltd, Ibaraki 302-0106, Japan.
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MeSH Terms
Antibody Formation / drug effects
Blood / immunology
Camellia sinensis / chemistry*,  genetics
Chromatography, High Pressure Liquid
Gallic Acid / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Hydrolyzable Tannins / chemistry,  isolation & purification*,  pharmacology
Immunoglobulin E / biosynthesis*
Immunosuppressive Agents / chemistry,  isolation & purification*,  pharmacology
Lymphocytes / drug effects*,  metabolism
Molecular Structure
Phenols / metabolism
Plant Extracts / chemistry*,  pharmacology
Plant Leaves / chemistry,  genetics
Quinic Acid / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Tea / chemistry
Reg. No./Substance:
0/1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-beta-D-glucopyranose; 0/Hydrolyzable Tannins; 0/Immunosuppressive Agents; 0/Phenols; 0/Plant Extracts; 0/Tea; 0/strictinin; 0/theogallin; 149-91-7/Gallic Acid; 37341-29-0/Immunoglobulin E; 77-95-2/Quinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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