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Identification of xanthones from Swertia punicea using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
MedLine Citation:
PMID:  23136022     Owner:  NLM     Status:  In-Data-Review    
RATIONALE: Swertia punicea Hemsl. (Gentianaceae) are used mainly for the treatment of acute bilious hepatitis, cholecystitis, fever, intoxification and jaundice in China, as a traditional Chinese folk medicine. Xanthones as the main chemical components of Swertia punicea have many possible pharmacological properties, such as hepatoprotective and anti-HIV. In order to obtain an overall picture of the xanthones of Swertia punicea, high-performance liquid chromatography diode-array detection/tandem mass spectrometry (HPLC/DAD-ESI-MS(n) ) was applied to the structural characterization of xanthones in ethyl acetate and acetone extracts.
METHODS: The ESI-MS fragmentation behaviors of xanthones were investigated based on the 17 reference xanthones and then applied to the structural characterization of xanthones in ethyl acetate and acetone extracts of Swertia punicea by HPLC/DAD-ESI-MS(n) .
RESULTS: The fragmentation rules of aglycone, C-glycosides, O-glycosides, and polyxanthones with different linkages were summarized. The observed fragmentation pathways were used successfully for the analysis of the xanthone constituents of Swertia punicea, and a total of 34 xanthones were identified, among which 16 compounds were new and one compound was reported from this species for the first time.
CONCLUSIONS: The described methods were very valuable for the identification of xanthones, especially of the trace compounds, and therefore could be utilized for sensitive and rapid qualitative analysis of xanthones in Swertia punicea. Copyright © 2012 John Wiley & Sons, Ltd.
Xin-Gang Du; Wei Wang; Qing-Ying Zhang; Jun Cheng; Bharathi Avula; Ikhlas A Khan; De-An Guo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  26     ISSN:  1097-0231     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  2913-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
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