Document Detail

Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds.
MedLine Citation:
PMID:  15998116     Owner:  NLM     Status:  MEDLINE    
Dietary ellagic acid and related polyphenols are metabolized in humans to dibenzopyran-6-one derivatives, and the microbial origin of these metabolites has been suggested. However, this has not been demonstrated so far. Fecal samples donated by six volunteers were incubated under anaerobic conditions, and aliquots were used to evaluate the fecal metabolism of ellagic acid, the ellagitannin punicalagin, and an ellagitannin rich extract from walnuts. The isoflavone daidzein was also incubated with the same fecal samples to follow the production of the microbial metabolites previously reported (dihydrogenistein, O-demethylangolensin, and equol) as a positive control of the system and to evaluate similarities between isoflavone and ellagic acid fecal flora metabolism. After fermentation the metabolite "urolithin A" (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one) was produced from ellagic acid, punicalagin, and the ellagitannin extract in all the fecal cultures from different volunteers, but with very different production rates and concentrations. This large variability in the concentration of metabolite and kinetics of metabolite production is consistent with the large variability found in the excretion of these metabolites in urine in vivo after human consumption of ellagitannins, and with differences in the composition of the fecal microflora. No correlation between isoflavone and ellagic acid metabolism by fecal microflora was observed. The present study confirms the microbial origin of the recently reported in vivo generated hydroxy-6H-dibenzo[b,d]pyran-6-one derivatives in humans and is a further step in the study of the bioavailability and metabolism of ellagic acid and ellagitannins.
Begoña Cerdá; Paula Periago; Juan Carlos Espín; Francisco A Tomás-Barberán
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  53     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-06     Completed Date:  2005-08-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5571-6     Citation Subset:  IM    
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus Universitario de Espinardo, Murcia, Spain.
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MeSH Terms
Bacteria / metabolism*
Colon / microbiology*
Coumarins / metabolism*
Ellagic Acid / administration & dosage,  metabolism*,  pharmacokinetics
Feces / microbiology
Flavonoids / administration & dosage,  metabolism
Hydrolyzable Tannins / administration & dosage,  metabolism
Isoflavones / metabolism
Phenols / administration & dosage,  metabolism
Reg. No./Substance:
0/Coumarins; 0/Flavonoids; 0/Hydrolyzable Tannins; 0/Isoflavones; 0/Phenols; 0/polyphenols; 1143-70-0/3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 476-66-4/Ellagic Acid

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