Document Detail


Identification of urinary metabolites of (+/-)-2-(p-isobutylphenyl)propionic acid (Ibuprofen) by routine organic acid screening.
MedLine Citation:
PMID:  1424159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ibuprofen [(+/-)-2-(p-isobutylphenyl)propionic acid] has recently been introduced as a pediatric anti-inflammatory agent. To determine how this agent interferes with urine organic acid analysis, an important pediatric investigation, we have analyzed urine from two subjects pre- and post-Ibuprofen dosage and two subjects on chronic Ibuprofen therapy. A distinctive pattern of drug interference on the organic acid profile was detected. There were three major components, corresponding to unmetabolized Ibuprofen and to the oxidation products hydroxy Ibuprofen and carboxy Ibuprofen. Therefore, the major mechanism of Ibuprofen metabolism appears to be microsomal, although mitochondrial and peroxisomal routes cannot be excluded. Laboratories carrying out routine organic acid analysis should be aware of the nature and magnitude of the organic aciduria caused by Ibuprofen.
Authors:
M J Bennett; W G Sherwood; A Bhala; D E Hale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  210     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-15     Completed Date:  1992-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Affiliation:
Metabolic Disease Center, Baylor University Medical Center, Dallas, TX 75246.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carboxylic Acids / urine*
Child, Preschool
Humans
Ibuprofen / chemistry,  urine*
Male
Mass Screening
Mass Spectrometry
Metabolism, Inborn Errors / urine
Molecular Structure
Molecular Weight
Quality Control
Chemical
Reg. No./Substance:
0/Carboxylic Acids; 15687-27-1/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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