Document Detail

Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3.
MedLine Citation:
PMID:  7868138     Owner:  NLM     Status:  MEDLINE    
Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somatic cell hybrid panel. Both polymorphisms showed heterozygosities of 0.83 in the unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These new markers should improve the map of the 21q22.3 region, which is believed to contain a large number of genes.
A Bosch; J Guimerà; S Wiemann; W Ansorge; D Patterson; X Estivill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  95     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-03-24     Completed Date:  1995-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  367-9     Citation Subset:  IM    
Molecular Genetics Department, Cancer Research Institute (IRO), Hospital Duran i Reynals, Barcelona, Catalunya, Spain.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/Z34970;  Z34973
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MeSH Terms
Base Sequence
Chromosomes, Human, Pair 21 / chemistry,  genetics*
DNA Primers
DNA, Satellite / genetics
Hybrid Cells
Minisatellite Repeats*
Molecular Sequence Data
Polymorphism, Genetic
Grant Support
Reg. No./Substance:
0/DNA Primers; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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