Document Detail


Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3.
MedLine Citation:
PMID:  7868138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somatic cell hybrid panel. Both polymorphisms showed heterozygosities of 0.83 in the unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These new markers should improve the map of the 21q22.3 region, which is believed to contain a large number of genes.
Authors:
A Bosch; J Guimerà; S Wiemann; W Ansorge; D Patterson; X Estivill
Related Documents :
10527808 - Molecular interpretation of expanded red products in bipolar disorder by cag/ctg repeat...
11018708 - De novo expansion of a cag repeat in a japanese patient with sporadic huntington's dise...
9651528 - Cloning of 5'-flanking region and a polymorphic ctt trinucleotide repeat within 5'-untr...
7951248 - Dominant optic atrophy (opa1) mapped to chromosome 3q region. i. linkage analysis.
1090568 - Detection of nonintegrated plasmid deoxyribonucleic acid in the folded chromosome of es...
8956878 - Translocation (6;9;22)(p25;q34;q11.2) identified by fish in acute leukemia.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  95     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-03-24     Completed Date:  1995-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  367-9     Citation Subset:  IM    
Affiliation:
Molecular Genetics Department, Cancer Research Institute (IRO), Hospital Duran i Reynals, Barcelona, Catalunya, Spain.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/Z34970;  Z34973
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosomes, Human, Pair 21 / chemistry,  genetics*
DNA Primers
DNA, Satellite / genetics
Humans
Hybrid Cells
Minisatellite Repeats*
Molecular Sequence Data
Polymorphism, Genetic
Grant Support
ID/Acronym/Agency:
HD17449/HD/NICHD NIH HHS; HG00716/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A TaqI polymorphism in the human erythroid beta spectrin gene.
Next Document:  Combined ultrasound and fluorescence spectroscopy for physico-chemical imaging of atherosclerosis.