Document Detail


Identification of the translocation t(15;17) in acute myeloid leukemia (AML) initially classified as FAB M1: case report and review of the literature.
MedLine Citation:
PMID:  16584058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a case of a patient aged about 53 years, who initially presented with hematological disorders (WBC: 44000/mm3, Hb: 11g/dl, Pit: 127000/mm3) without tumoral syndrome. The Wright-Giemsa stained bone marrow and peripheral blood smears showed a population of blast cells characterized by cells with high N/C and strongly basophilic cytoplasm without granules. The nuclei were predominantly round. Nuclear chromatin was fine and contained small nucleoli. Cytochemisty was positive for peroxidase activity. Immunophenotyping showed myeloid typical markers of granulocytic lineage (MP0+, CD13+, CD33+, CD117+, CD34-). The karyotype revealed the expression of t(15;17) chromosomal translocation. The diagnosis of acute myeloid leukaemia (AML) was then evoked initially. The cytological features corresponded closely to the M1 subtype as defined in the FAB classification. The patient was treated with induction therapy according to the 7/3 protocol. One month later, he was discharged from hospital on hematological and cytogenetic remission. He died at home because of a heart attack. From the biological findings the patient was retrospectively diagnosed as having promyelocytic leukemia (hyperbasophilic form).
Authors:
N Braham Jmili; H Omri; H Senana Sendi; S Fekih; S Hizem; B Sriha; A Khelif; A Saad; M Kortas
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical laboratory     Volume:  52     ISSN:  1433-6510     ISO Abbreviation:  Clin. Lab.     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-04-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9705611     Medline TA:  Clin Lab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Affiliation:
Laboratoire d'Hématologie, CHU FARHA T HACHED Sousse, Tunisie. jmilinejia@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow Cells / enzymology,  pathology
Chromosome Banding
Chromosomes, Human, Pair 15*
Chromosomes, Human, Pair 17*
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics*,  metabolism,  pathology
Leukemia, Promyelocytic, Acute / genetics*,  metabolism,  pathology
Male
Middle Aged
Neoplasms, Second Primary / genetics*,  metabolism,  pathology
Peroxidase / metabolism
Translocation, Genetic*
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 1.11.1.7/Peroxidase

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