Document Detail


Identification of a toxic mechanism of the plasticizers, phtahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate.
MedLine Citation:
PMID:  12596868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have reported that the administration of di(2-ethylhexyl)phthalate (DEHP) increased the formations of quinolinic acid (QA) and its lower metabolites on the tryptophan-niacin pathway. To discover the mechanism involved in disruption of the tryptophan-niacin pathway by DEHP, we assessed the daily urinary excretion of QA and its lower metabolites, and enzyme activities on the tryptophan-niacin pathway. Rats were fed with a niacin-free, 20% casein diet or the same diet supplemented with 0.1% DEHP or 0.043% phthalic acid and 0.067% 2-ethylhexanol added for 21 days. Feeding of DEHP increased the urinary excretions of QA and its lower metabolites in a time-dependent manner, and the increase of these excretions reached a peak at 11 days, but feeding of phthalic acid and 2-ethylhexanol had no effect. Feeding of DEHP, however, did not affect any enzyme activity including alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), affecting the formation of QA, on the tryptophan-niacin pathway.
Authors:
Tsutomu Fukuwatari; Yuko Suzuki; Etsuro Sugimoto; Katsumi Shibata
Related Documents :
3573868 - Influence of urinary ph on pethidine kinetics in healthy volunteer subjects. 2. a study...
90138 - Urinary glycosaminoglycans in patients with progressive myoclonus epilepsy.
2347648 - Effect of ethanol on the urinary excretion of mandelic and phenylglyoxylic acids after ...
9099368 - Urinary excretion of specific mercapturic acids in workers exposed to styrene.
3573868 - Influence of urinary ph on pethidine kinetics in healthy volunteer subjects. 2. a study...
90138 - Urinary glycosaminoglycans in patients with progressive myoclonus epilepsy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  66     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2687-91     Citation Subset:  IM    
Affiliation:
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, Japan. fukkie@shc.usp.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Carboxy-Lyases / metabolism
Diethylhexyl Phthalate / metabolism,  pharmacology*,  toxicity*
Feeding Behavior / drug effects
Hexanols / metabolism
Liver / drug effects,  enzymology,  metabolism
Niacin / metabolism
Quinolinic Acid / metabolism*,  urine
Rats
Tryptophan / metabolism
Chemical
Reg. No./Substance:
0/Hexanols; 104-76-7/2-ethylhexanol; 117-81-7/Diethylhexyl Phthalate; 59-67-6/Niacin; 73-22-3/Tryptophan; 89-00-9/Quinolinic Acid; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.45/aminocarboxymuconate-semialdehyde decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate recepto...
Next Document:  Identification of (3S, 9R)- and (3S, 9S)-megastigma-6,7-dien-3,5,9-triol 9-O-beta-D-glucopyranosides...