Document Detail

Identification of a toxic mechanism of the plasticizers, phtahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate.
MedLine Citation:
PMID:  12596868     Owner:  NLM     Status:  MEDLINE    
We have reported that the administration of di(2-ethylhexyl)phthalate (DEHP) increased the formations of quinolinic acid (QA) and its lower metabolites on the tryptophan-niacin pathway. To discover the mechanism involved in disruption of the tryptophan-niacin pathway by DEHP, we assessed the daily urinary excretion of QA and its lower metabolites, and enzyme activities on the tryptophan-niacin pathway. Rats were fed with a niacin-free, 20% casein diet or the same diet supplemented with 0.1% DEHP or 0.043% phthalic acid and 0.067% 2-ethylhexanol added for 21 days. Feeding of DEHP increased the urinary excretions of QA and its lower metabolites in a time-dependent manner, and the increase of these excretions reached a peak at 11 days, but feeding of phthalic acid and 2-ethylhexanol had no effect. Feeding of DEHP, however, did not affect any enzyme activity including alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), affecting the formation of QA, on the tryptophan-niacin pathway.
Tsutomu Fukuwatari; Yuko Suzuki; Etsuro Sugimoto; Katsumi Shibata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  66     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2687-91     Citation Subset:  IM    
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, Japan.
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MeSH Terms
Body Weight / drug effects
Carboxy-Lyases / metabolism
Diethylhexyl Phthalate / metabolism,  pharmacology*,  toxicity*
Feeding Behavior / drug effects
Hexanols / metabolism
Liver / drug effects,  enzymology,  metabolism
Niacin / metabolism
Quinolinic Acid / metabolism*,  urine
Tryptophan / metabolism
Reg. No./Substance:
0/Hexanols; 104-76-7/2-ethylhexanol; 117-81-7/Diethylhexyl Phthalate; 59-67-6/Niacin; 73-22-3/Tryptophan; 89-00-9/Quinolinic Acid; EC 4.1.1.-/Carboxy-Lyases; EC decarboxylase

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