| Identification of tiagabine degradation products using liquid chromatography with electrospray ionization multistage mass spectrometry and ultra-performance liquid chromatography/high-resolution mass spectrometry. | |
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MedLine Citation:
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PMID: 22223315 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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RATIONALE: Tiagabine hydrochloride monohydrate drug substance (TGB) is an antiepileptic agent effective in the treatment of seizure disorders. The stability of TGB was studied and its degradation products were identified for the first time. METHODS: TGB was heated in the presence of H(2) O(2) . Degradation products were analyzed by liquid chromatography coupled to electrospray ionization multistage mass spectrometry (LC/ESI-MS(n) ) and high-resolution mass spectrometry (HR-MS). RESULTS: This study showed that TGB was degraded by oxidative pathways involving attack of oxygen at different centers but mainly at the double bond of the molecule. The oxidative cascade reactions initiated by the epoxidation of the double bond of tiagabine led to dihydroxy, ketohydroxy and ketone derivatives as well as bisthiophene ketone. CONCLUSIONS: Nine degradation products of TGB were identified. Some diagnostic MS/MS product ions, characteristic of the piperidine or thiophene moiety, were highlighted. Copyright © 2012 John Wiley & Sons, Ltd. |
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Authors:
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Marie Hubert-Roux; Mohamed Skiba; Abdussalam Sughir; Malika Lahiani-Skiba; Fabienne Olivier-Chanu; Vincent Levacher; Catherine M Lange |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rapid communications in mass spectrometry : RCM Volume: 26 ISSN: 1097-0231 ISO Abbreviation: Rapid Commun. Mass Spectrom. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802365 Medline TA: Rapid Commun Mass Spectrom Country: England |
Other Details:
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Languages: eng Pagination: 287-96 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 John Wiley & Sons, Ltd. |
Affiliation:
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Université de Rouen, CNRS-UMR6014, Rue tesnières, 76821, Mont-Saint-Aignan cedex, France; CNRS-UMR 6014 (COBRA), rue Tesnières, 76821, Mont-Saint-Aignan cedex, France; CNRS FR 3038, rue Tesnières, 76130, Mont-Saint-Aignan, France. marie.hubert@univ-rouen.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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