Document Detail


Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition.
MedLine Citation:
PMID:  18550601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thioredoxin-2 (Trx2) is a multifunctional, mitochondria-specific protein, which inhibits cell death. The mitochondrial permeability transition (MPT) is a distinct mechanism for cell death activated by oxidants and linked to both necrotic and apoptotic morphologies. We studied mitochondria from Trx2 transgenic mice to determine whether Trx2 protects against oxidant-induced MPT. All experiments were performed in isolated mitochondria. Results showed that Trx2 protected against MPT induced by exogenously added peroxide. Unexpectedly, Trx2 also protected against the MPT induced by Ca(2+) in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT.
Authors:
Min He; Jiyang Cai; Young-Mi Go; Jennifer M Johnson; W David Martin; Jason M Hansen; Dean P Jones
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-06-11
Journal Detail:
Title:  Toxicological sciences : an official journal of the Society of Toxicology     Volume:  105     ISSN:  1096-0929     ISO Abbreviation:  Toxicol. Sci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-10-23     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  9805461     Medline TA:  Toxicol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
Affiliation:
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Calcium / metabolism
Female
MAP Kinase Kinase Kinase 5 / physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mitochondrial Membrane Transport Proteins*
Oxidative Stress
Thioredoxins / physiology*
Grant Support
ID/Acronym/Agency:
ES009047/ES/NIEHS NIH HHS; ES014668/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Mitochondrial Membrane Transport Proteins; 0/Txn2 protein, mouse; 0/mitochondrial permeability transition pore; 52500-60-4/Thioredoxins; 7440-70-2/Calcium; EC 2.7.11.25/MAP Kinase Kinase Kinase 5; EC 2.7.11.25/Map3k5 protein, mouse
Comments/Corrections

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