Document Detail


Identification of thiol-activated T-kininogenases in the rat and mouse submandibular glands.
MedLine Citation:
PMID:  2610077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T-kininogen is a unique protein(s) which is directed for synthesis following inflammation such as that caused by adjuvant arthritis and carrageenin. The properties of the protein include thiol-protease inhibition and the potential to act as a substrate to release Ile-Ser-bradykinin (T-kinin). During the inflammatory response, free T-kinin is found in the blood and inflammatory fluids indicating that T-kininogenase (T-kgnase) enzymes exist that release T-kinin and perhaps related T-kinins involved in inflammation. We report here that T-kininogenases have been found in the rat and mouse submandibular glands and in rat peritoneal white cells. The pH optimum is about 8.0. The enzymes must be thiol-activated. Thus, the rat has the complete T-kgnase-T-kinin system. Since T-kininogen is a member of the superfamily of cysteine protease inhibitors, members of the superfamily may be directed for synthesis in inflammatory diseases including ascites in other species including humans.
Authors:
A Barlas; X Gao; L M Greenbaum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  247B     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-09     Completed Date:  1990-02-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, School of Graduate Studies, Medical College of Georgia, Augusta 30912.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bradykinin / analogs & derivatives,  blood,  metabolism
Carrageenan / pharmacology
Guinea Pigs
Inflammation
Kallikreins / metabolism*
Mice
Rats
Submandibular Gland / enzymology*
Sulfhydryl Compounds
Chemical
Reg. No./Substance:
0/Sulfhydryl Compounds; 58-82-2/Bradykinin; 86030-63-9/T-kinin; 9000-07-1/Carrageenan; EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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