| Identification of systemic markers from a pulmonary carbon nanotube exposure. | |
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MedLine Citation:
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PMID: 21654424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: : Interest exists for early monitoring of worker exposure to engineered nanomaterials. Here, we highlight quantitative systemic markers of early effects after carbon nanotube (CNT) exposure. METHODS: : Mice were exposed by pharyngeal aspiration to 40-μg CNT and harvested 24 hours, 7 days, and 28 days postexposure for measurements of whole blood, lung and extrapulmonary tissue gene expression, blood and bronchoalveolar lavage (BAL) differentials, and serum protein profiling. RESULTS: : Early effects included increased inflammatory blood gene expression and serum cytokines followed by an acute phase response (eg, CRP, SAA-1, SAP). Beyond 24 hours, there was a consistent increase in blood and BAL eosinophils. At 28 day, serum acute phase proteins with immune function including complement C3, apolipoproteins A-I and A-II, and α2-macroglobulin were increased. CONCLUSIONS: : Carbon nanotube exposure resulted in measurable systemic markers but lacked specificity to distinguish from other pulmonary exposures. |
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Authors:
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Aaron Erdely; Angie Liston; Rebecca Salmen-Muniz; Tracy Hulderman; Shih-Houng Young; Patti C Zeidler-Erdely; Vincent Castranova; Petia P Simeonova |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine Volume: 53 ISSN: 1536-5948 ISO Abbreviation: J. Occup. Environ. Med. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504688 Medline TA: J Occup Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: S80-6 Citation Subset: IM |
Affiliation:
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From the Toxicology and Molecular Biology Branch (Dr Erdely, Dr Simeonova, Ms Liston, Ms Salmen-Muniz, Ms Hulderman), Pathology and Physiology Research Branch (Dr Young, Dr Zeidler-Erdely, Dr Castranova), and Laboratory of Occupational Cardiovascular Toxicology (Dr Erdely, Dr Castranova, Ms Salmen-Muniz, Ms Hulderman), Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WVa. †Deceased. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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