Document Detail


Identification of superoxide dismutase in rat liver peroxisomes.
MedLine Citation:
PMID:  1739741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper we have investigated whether or not superoxide dismutase is localized in peroxisomes from rat liver. Using an improved method to prepare peroxisomes from clofibrate induced rat livers, we identified superoxide dismutase activity in peroxisomes. This activity was found to be predominantly of the copper-zinc type. The finding of superoxide dismutase activity in peroxisomes makes sense since peroxisomes also contain superoxide generating enzyme activities such as xanthine oxidase.
Authors:
R J Wanders; S Denis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1115     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-24     Completed Date:  1992-03-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, University Hospital Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Fractionation
Centrifugation, Density Gradient
Liver / enzymology*,  ultrastructure
Male
Microbodies / enzymology*
Potassium / pharmacology
Rats
Rats, Inbred Strains
Superoxide Dismutase / analysis*,  antagonists & inhibitors
Chemical
Reg. No./Substance:
7440-09-7/Potassium; EC 1.15.1.1/Superoxide Dismutase

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