Document Detail

Identification of substances with potential for long-range transport as possible substances of very high concern.
MedLine Citation:
PMID:  22752812     Owner:  NLM     Status:  MEDLINE    
According to the European legislation, REACH, organic compounds are considered as substances of very high concern (SVHC) if they are persistent, bioaccumulative and toxic (PBT). A substance's long-range transport potential (LRTP) may also pose a risk to remote regions. This is, however, not yet explicitly included. For identification of compounds, which are not PBT according to REACH criteria, but show LRTP, we investigated 22,438 compounds from the Canadian Domestic Substance List (CDSL). The CDSL was searched for organic, neutral compounds. Substance properties were estimated with EPI Suite v4.00. Next, the substance list was edited in two ways: (1) The half-life criterion in air for LRTP as defined in the Stockholm Convention was applied. (2) For all compounds, indicators for persistence and LRTP were calculated with the multimedia model ELPOS v2.2. Applying the half-life criterion, we identified 594 substances, which are prone to LRT but are not PBT (non-PBT-L substances). In contrast, investigations with ELPOS lead to a shorter list of 188 substances, which are non-PBT-L substances. Finally, the list was compared with potential Arctic contaminants identified in previous literature. Our results show that there is a large number of organic chemicals which would not be considered as SVHC since they are not, at the same time, persistent, bioaccumulative and toxic according to REACH criteria. Nevertheless, they show LRTP according to different screening approaches and thus a potential hazard to remote regions.
Christiane Zarfl; Ines Hotopp; Nils Kehrein; Michael Matthies
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-01
Journal Detail:
Title:  Environmental science and pollution research international     Volume:  19     ISSN:  1614-7499     ISO Abbreviation:  Environ Sci Pollut Res Int     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-09     Completed Date:  2012-10-26     Revised Date:  2013-09-11    
Medline Journal Info:
Nlm Unique ID:  9441769     Medline TA:  Environ Sci Pollut Res Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3152-61     Citation Subset:  IM    
Institute of Environmental Systems Research, University of Osnabrück, Barbarastr. 12, 49076 Osnabrück, Germany.
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MeSH Terms
Air Pollutants / chemistry*,  toxicity
Air Pollution / legislation & jurisprudence
Arctic Regions
Hazardous Substances* / toxicity
Models, Chemical
Organic Chemicals / chemistry*,  toxicity
Reg. No./Substance:
0/Air Pollutants; 0/Hazardous Substances; 0/Organic Chemicals
Comment In:
Environ Sci Pollut Res Int. 2013 Aug;20(8):5878   [PMID:  23681774 ]
Environ Sci Pollut Res Int. 2013 Aug;20(8):5876-7   [PMID:  23709266 ]

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