| Identification and stability of a new bichalcone in Achyrocline satureioides spray dried powder. | |
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MedLine Citation:
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PMID: 21038841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new chemical structure, the 4,2',4",2'''-tetrahydroxy-6',6'''-dimethoxy-4'-O-4'''- bichalcone, named achyrobichalcone was isolated and identified from an Achyrocline satureioides spray-dried powder (SDP80). The thermal and photo stability of this new compound as well as that of the main polyphenols present in the spray dried powder, quercetin, luteolin, 3-O-metylquercetin and the corresponding kinetics of degradation are reported. In the long-term testing (30 +/- 2 degrees C/75 +/- 5% RH, 12 months), the total polyphenols contained in SDP80 demonstrated to be stable, remaining higher than 90% after a 12 month exposure. The photo stability testing revealed that all polyphenols were stable for 48 h when SDP80 was conditioned in amber or transparent flasks and exposed to UV-C radiation (light express LE UV, 254 nm, 30W). In contrast, when unprotected, the polyphenols demonstrated to be sensitive to both, thermal stress testing (80 +/- 2 degrees C), for 14 days and to UV-C radiation. Luteolin showed to be the most stable against UVC light and 3-O-methylquercetin against temperature. The achyrobichalcone demonstrated to be the more unstable against both, temperature and light. The kinetics of polyphenol thermal degradation (80 +/- 2 degrees C, 49 days) and photodegradation (UV-C radiation, 96 h) followed, 2nd and 1st order reaction, respectively. |
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Authors:
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M H Holzschuh; G Gosmann; P H Schneider; E E S Schapoval; V L Bassani |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 65 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 650-6 Citation Subset: IM |
Affiliation:
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Programa de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Achyrocline
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chemistry* Chalcones / analysis*, radiation effects Chromatography, High Pressure Liquid Desiccation Drug Stability Ethanol Hot Temperature Kinetics Light Magnetic Resonance Spectroscopy Phenols / analysis, radiation effects Plant Extracts / analysis Powders Reference Standards Solvents |
| Chemical | |
Reg. No./Substance:
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0/Chalcones; 0/Phenols; 0/Plant Extracts; 0/Powders; 0/Solvents; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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